منابع مشابه
Multiple Sequence Alignments in Linguistics
In this study we apply and evaluate an iterative pairwise alignment program for producing multiple sequence alignments, ALPHAMALIG (Alonso et al., 2004), using as material the phonetic transcriptions of words used in Bulgarian dialectological research. To evaluate the quality of the multiple alignment, we propose two new methods based on comparing each column in the obtained alignments with the...
متن کاملEvolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal multiple sequence alignment is prohibitively expensive. Heuristic alignment algorithms represent a practical trade-off between speed and accuracy, but they can be improved. We present EVALYN (EVolved ALYNments), a novel...
متن کاملMultiple Sequence Alignments with Parallel Computing
The growth of bioinformatics and computational biology industry, multiple sequence alignment (MSA) applications have become an important emerging workload. In spite of the large amount of recent attention given to the MSA software design, there has been little quantitative understanding of the performance of such applications on modern microprocessors and systems. In this paper we try to analyz...
متن کاملEvaluation Measures of Multiple Sequence Alignments
Multiple sequence alignments (MSAs) are frequently used in the study of families of protein sequences or DNA/RNA sequences. They are a fundamental tool for the understanding of the structure, functionality and, ultimately, the evolution of proteins. A new algorithm, the Circular Sum (CS) method, is presented for formally evaluating the quality of an MSA. It is based on the use of a solution to ...
متن کاملOptimal Alignment of Multiple Sequence Alignments
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 CHAPTER 1: INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . 14 1.1 Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 1.2 Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 1.3 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2005
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2005.04.002